Phenotypic and genotypic characterization of clinical carbapenem-resistant <i>Acinetobacter</i> species harboring the metallo-beta-lactamases IMP-8 or NDM-1 in China
Given the low prevalence of IMP among <i>A. baumannii</i> and the limited sequencing technology in earlier years, research on <i>bla</i><sub>IMP</sub> in <i>A. baumannii</i> is scarce, and genetic information on <i>bla</i><sub>NDM-1</sub>-producing <i>Acinetobacter</i> spp. strains isolated in earlier years is limited. This study revisited five MBL-carrying <i>Acinetobacter</i> spp. strains isolated in 2010, characterizing their phenotypic and genotypic features. This retrospective analysis serves as a form of "bacterial archaeology," providing evidence of the evolutionary changes in genetic elements conferring antibiotic resistance.
Authors
- Yunsong Yu (ORCID: https://orcid.org/0000-0003-2903-918X)
- Haiyang Liu (ORCID: https://orcid.org/0000-0001-6332-6751)
- Qingye Xu (ORCID: https://orcid.org/0000-0002-8191-9478)
- Jintao He (ORCID: https://orcid.org/0000-0002-4412-9661)
- Xiaochen Liu (ORCID: https://orcid.org/0000-0001-8286-6366)
- Xiaoting Hua (ORCID: https://orcid.org/0000-0001-8215-916X)
- Yanfei Wang (ORCID: https://orcid.org/0000-0002-4797-7498)
- Xinli Mu
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Institute of Microbial Technology (IN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1128/spectrum.01158-24
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province