Effects and mechanisms of long-acting glucagon-like peptide-1 receptor agonist semaglutide on microglia phenotypic transformation and neuroinflammation after cerebral ischemia/reperfusion in rats
In the CIRI model, semaglutide exhibits notable neuroprotective effects on rats, reducing neuroinflammation through the regulation of microglia phenotype transformation and inhibition of NF-κB activation.
Authors
- Fankai Gao
- Rulin Mi
- Rui Chen (ORCID: https://orcid.org/0000-0002-3813-1749)
- Li An (ORCID: https://orcid.org/0000-0002-8297-7776)
- Bo Bai (ORCID: https://orcid.org/0000-0001-9988-8318)
- Guofang Xue (ORCID: https://orcid.org/0000-0001-9235-5236)
- Hui-Feng Cheng
Institutions
- Shanxi Medical University (CN)
- Southern University of Science and Technology (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Brain Circulation
- Published
- 2024-10-01
- DOI
- https://doi.org/10.4103/bc.bc_38_24
- Citations
- 19
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.70