Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology

Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta-amyloid peptide (Aβ), has a prion-like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. All of them developed multiple cerebral hemorrhages, transient focal neurological deficits, and/or cognitive impairment after 3-4 decades. MRI was compatible with CAA, and Aβ deposition was confirmed. The third patient, who had a ventriculoperitoneal valve, also showed Aβ deposition in the peritoneum and diagnostic biomarkers of Alzheimer's disease. Co-pathology with Alzheimer disease and its iatrogenic transmission should be considered.

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Publication Details

Journal
Annals of Clinical and Translational Neurology
Published
2024-12-27
DOI
https://doi.org/10.1002/acn3.52278
Citations
1
Primary Topic
Intracerebral and Subarachnoid Hemorrhage Research
Type
article
Field-Weighted Citation Impact
0.37
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Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology

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article en
1 citations

Abstract

Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta-amyloid peptide (Aβ), has a prion-like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. All of them developed multiple cerebral hemorrhages, transient focal neurological deficits, and/or cognitive impairment after 3-4 decades. MRI was compatible with CAA, and Aβ deposition was confirmed. The third patient, who had a ventriculoperitoneal valve, also showed Aβ deposition in the peritoneum and diagnostic biomarkers of Alzheimer's disease. Co-pathology with Alzheimer disease and its iatrogenic transmission should be considered.

Annals of Clinical and Translational NeurologyVol. 12(1)
University Hospital Complex Of Vigo (ES), Hospital General Universitario de Ciudad Real (ES), Vall d'Hebron Hospital Universitari (ES), Hospital General Universitario de Albacete (ES)
Good health and well-being
Openalex Percentile: Top 32%
Intracerebral and Subarachnoid Hemorrhage Research
0.37
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