Effects of experimentally induced toxoplasmosis on blood glucose in albino mice Balb/c

Toxoplasmosis is one of the most important and prevalent disease affecting a wide range of hosts. It is caused by the parasite called T.gondii. The present study aimed to evaluate the blood glucose in serum in albino mice Balb/c induced toxoplasmosis serum. Ten placenta samples were collected from aborted women from Al-Batoul and Al-Salam Hospital in Mosul city from October 2023 to December 2024 . Eighty mice were infected experimentally with toxoplasmosis (20 male and 20 female) by injecting tissue cysts isolated from the placenta into the peritoneal cavity of laboratory mice and five mice were dissected after each after 1, 2, 3, and 6 weeks post infection (p.i)).A serum was collected to determine the glucose and insulin levels, and the titer of anti-portant toxoplasma antibodies was measured using an ELISA kit. The number of tissue cysts in the impressions brain was numerate. Results showed an increase in glucose level concentration in all groups. The highest rate of glucose was recorded in infected males after the sixth week p.i (167.40±9.46)mg/dl. The highest increase in insulin levels was recorded in all infected groups (male and female) at all periods compared to control. Furthermore, There were significant differences in the rate of IgG antibody titer, as the highest rate of antibody concentration was recorded at the first-week p.i in female (0.54±0.06) titer .Also, the results showed significant differences in the number of cysts in all groups at the sixth week post–infected.