Cortical lesions impact cognitive decline in multiple sclerosis via volume loss of nonlesional cortex
Multiple sclerosis-related cortical thinning was worse in lesional compared to normal-appearing cortex, while volume loss of normal-appearing cortex was most predictive of subsequent cognitive decline, particularly in the default mode network. Mediation analyses indicate that cortical lesions impact cognitive decline plausibly by inducing atrophy, rather than through a direct effect.
Authors
- Albulena Bajrami (ORCID: https://orcid.org/0000-0002-6322-9545)
- Maureen van Dam (ORCID: https://orcid.org/0000-0002-4639-5138)
- Bernard M.J. Uitdehaag (ORCID: https://orcid.org/0000-0002-9226-7364)
- Samantha Noteboom (ORCID: https://orcid.org/0000-0003-4796-8636)
- Ismail Koubiyr (ORCID: https://orcid.org/0000-0001-7185-7974)
- Eric C. Klawiter (ORCID: https://orcid.org/0000-0002-3429-2633)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Piet M. Bouman (ORCID: https://orcid.org/0000-0003-2698-4004)
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Eva A. Krijnen (ORCID: https://orcid.org/0000-0002-3628-4127)
- Martijn D. Steenwijk
Institutions
- Leiden University (NL)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Amsterdam Neuroscience (NL)
- Provincia Autonoma di Trento (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1002/acn3.52261
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- ZonMw