SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL INVESTIGATION OF Ni[II], Cu[II] Co[II], Zn[II], Mn[II] METAL COMPLEXES OF TETRADENTATE SCHIFF BASE LIGAND

Biological active Schiff base (HPMBP) was prepared from 2,4-Diamino-6hydroxypyrimidine and 5-bromo-2-hydroxybenzaldehyde by condensation method.A series of novel Ni[II], Cu[II] Co(II), Zn(II) and Mn(II) complexes have been synthesized from Schiff base ligand (HPMBP).The structural features and physical properties of Schiff base ligand (HPMBP)and their metal complexes were explored from spectral characterization techniques such as 1 H NMR, 13 C NMR, Mass, FT-IR spectra, P-XRD and TGA.The spectral analysis data shows that the metal complexes have composition of ML(1:1) type.The P-XRD data propose monoclinic crystal system for Ni(II), Co(II), Zn(II), Mn(II) complexes and orthorombhic crystal system for Cu(II) complex.The bio-efficiency of ligand and its transition metal complexes have been tested against three gram +ve /gram -ve bacteria (Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumonia) and four fungi (Penicillium chrysogenum, Trichoderma viride, Aspergillus niger and Candida albicans) in vitro to examine their microbial activity.The bioactivity data reveals that the metal complexes showed good antifungal and antibacterial activity than the Schiff base ligand (HPMBP).