Application of the 6-SNP elevated LDL-cholesterol polygenic risk score in individuals with familial hypercholesterolemia phenotype from an Argentine population
We present an estimate of the first cut-off value for the GRS-6 in a Latin American population, and we conclude that the GRS-6 could contribute to the evaluation of the polygenic contribution in cases with severe hypercholesterolemia in our population in a similar way to that of other European populations.
Authors
- Laura Schreier (ORCID: https://orcid.org/0000-0002-6973-055X)
- Virginia Bañares
- Pablo Corral (ORCID: https://orcid.org/0000-0003-0017-8725)
- Javier Martini (ORCID: https://orcid.org/0000-0001-8219-5929)
- Graciela López
Institutions
- Universidad de Buenos Aires (AR)
- Administración Nacional de Laboratorios e Institutos de Salud (AR)
- Universidad Fraternidad de Agrupaciones Santo Tomás de Aquino (AR)
- Instituto de Química y Fisicoquímica Biológicas (AR)
Publication Details
- Journal
- Gaceta Médica de México
- Published
- 2024-12-27
- DOI
- https://doi.org/10.24875/gmm.m24000918
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Alberto J. Roemmers