ENPP2 promotes progression and lipid accumulation via AMPK/SREBP1/FAS pathway in chronic lymphocytic leukemia
Taken together, our findings unravel the lipid metabolism characteristics of CLL. Moreover, we demonstrate a previously unidentified role and mechanism of ENPP2 in regulation of lipid metabolism, providing a novel therapeutic target for CLL treatment.
Authors
- Liyan Lu
- Tian Zheng (ORCID: https://orcid.org/0000-0003-4889-0391)
- Xin Wang (ORCID: https://orcid.org/0000-0002-5122-2418)
- Hua Wang (ORCID: https://orcid.org/0000-0002-5728-7714)
- Han Yang (ORCID: https://orcid.org/0000-0002-8791-3616)
- Ya Zhang (ORCID: https://orcid.org/0000-0003-0894-4922)
- Xinting Hu
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Taishan University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s11658-024-00675-6
- Citations
- 7
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 3.07
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province
- Taishan Scholar Foundation of Shandong Province
- Shandong First Medical University
- Key Technology Research and Development Program of Shandong