Knockdown of RASD1 improves MASLD progression by inhibiting the PI3K/AKT/mTOR pathway
We discovered a novel role of RASD1 in MASLD by regulating lipogenesis via the PI3K/AKT/mTOR pathway, thereby identifying a potential treatment target for MASLD.
Authors
- Guifang Zeng
- Peiping Li (ORCID: https://orcid.org/0000-0003-0861-3111)
- Xialei Liu (ORCID: https://orcid.org/0000-0001-8534-3026)
- Wenfeng Zhuo (ORCID: https://orcid.org/0009-0007-9069-2328)
- Zhaomin Zheng (ORCID: https://orcid.org/0000-0003-3758-1681)
- Chaonong Cai
- Baojia Zou (ORCID: https://orcid.org/0000-0001-8023-3434)
- Jiali Zhao (ORCID: https://orcid.org/0000-0003-2283-2361)
- Jian Li (ORCID: https://orcid.org/0000-0003-4517-5819)
- Shanglin Cai
- Zirui Bai
- En Lin
Institutions
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12944-024-02419-z
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province