Familial hypercholesterolemia in Chinese children and adolescents: a multicenter study
This study reveals the variable genotypes and phenotypes of children with FH in China and illustrates that the genotypes in the Chinese population differ from those in Caucasians, providing a valuable dataset for the clinical genetic screening of FH in China. Furthermore, the older age at diagnosis and treatment highlights the underdiagnosis and undertreatment of Chinese FH pediatric patients, suggesting that early identification should be improved through lipid or genetic screening, and that more timely and regular pharmacological treatments should be implemented.
Authors
- Chi Mei-zhu
- Xiaoming Ying (ORCID: https://orcid.org/0000-0001-5196-3497)
- Xiaoquan Chen
- Chaochun Zou (ORCID: https://orcid.org/0000-0002-4667-3636)
- Qing Zhou (ORCID: https://orcid.org/0000-0002-1917-5105)
- Ming-Qiang Zhu
- Chen Wang
- Xiaoxia Qian
- Jian-hua Feng
- Yaying Cheng (ORCID: https://orcid.org/0000-0001-8889-3509)
- Qiang Shen (ORCID: https://orcid.org/0000-0002-0867-6668)
- Junfen Fu (ORCID: https://orcid.org/0000-0001-6405-1251)
- Rui Gu (ORCID: https://orcid.org/0000-0002-5082-1574)
- Jianping Zhang (ORCID: https://orcid.org/0000-0003-0343-2071)
- Zhenjie Zhang (ORCID: https://orcid.org/0000-0003-2053-3771)
- Chunlin Wang (ORCID: https://orcid.org/0000-0003-4807-1644)
- Lifang Liu (ORCID: https://orcid.org/0000-0002-0315-2048)
- Ke Huang (ORCID: https://orcid.org/0000-0003-4832-9692)
- Mei Lü (ORCID: https://orcid.org/0000-0003-3019-307X)
- Lihong Jiang (ORCID: https://orcid.org/0000-0002-3042-6817)
- Dayan Wang
- Meng-Na Huang
- Qing Ke (ORCID: https://orcid.org/0000-0001-7415-8052)
- Mingsheng Ma
- Min Wang (ORCID: https://orcid.org/0000-0003-2052-199X)
Institutions
- Xiamen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- Sheng Jing Hospital (CN)
- Peking Union Medical College Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Fujian Women and Children Hospital (CN)
- Hebei General Hospital (CN)
- Children's Hospital of Zhejiang University (CN)
- Lishui Maternity and Child Health Care Hospital (CN)
- Taizhou First People's Hospital (CN)
- First People's Hospital of Nanning (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Tianjin Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12944-024-02406-4
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China