Symptoms Prior to Diagnosis of Multiple Sclerosis in Individuals Younger Than 18 Years
In this population-based, matched case-control study, children and adolescents with MS had diverse metabolic, ocular, musculoskeletal, gastrointestinal, and cardiovascular symptoms, signs, or diagnoses within 5 years before their first MS diagnosis. Better characterization of early symptoms and/or risk factors, comorbid disorders, and possible prodromal features of MS may have considerable implications for early recognition and subsequent progression of the disease.
Authors
- Jörg Bätzing (ORCID: https://orcid.org/0000-0001-7609-8559)
- Claudia Kohring (ORCID: https://orcid.org/0000-0002-1865-1923)
- Helen Tremlett (ORCID: https://orcid.org/0000-0001-5804-2535)
- David Ellenberger (ORCID: https://orcid.org/0000-0002-2274-5025)
- Jonas Graf (ORCID: https://orcid.org/0000-0002-4249-4665)
- Manas K. Akmatov (ORCID: https://orcid.org/0000-0003-2310-3179)
- Jakob Holstiege (ORCID: https://orcid.org/0000-0003-1337-6640)
Institutions
- University of British Columbia (CA)
- Düsseldorf University Hospital (DE)
- Hannover Re (Germany) (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.52652
- Citations
- 6
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.55