Molecular characterization of ovarian mesonephric-like adenocarcinoma: Insights from single-cell RNA sequencing and mitochondrial metabolism
This study provides the first scRNA-seq-based molecular characterization of ovarian MLA, differentiating it from HGSOC. Findings suggest potential therapeutic avenues, with a proposed combination therapy targeting MAP kinase and PI3K/AKT/mTOR pathways. Validation in larger cohorts is necessary for clinical application.
Authors
- Ye-Ah Kim
- Man S. Kim (ORCID: https://orcid.org/0000-0002-1507-9829)
- Hanbyoul Cho (ORCID: https://orcid.org/0000-0002-6177-1648)
- Gwan Hee Han (ORCID: https://orcid.org/0000-0001-5263-4855)
- Hyunjin Park (ORCID: https://orcid.org/0000-0001-5681-8918)
- Jae-Hoon Kim (ORCID: https://orcid.org/0000-0002-4410-9126)
- Hee Yun
Institutions
- Yonsei University (KR)
- Kyung Hee University (KR)
- Inje University Sanggye Paik Hospital (KR)
- Gangnam Severance Hospital (KR)
- Kyung Hee University Hospital at Gangdong (KR)
Publication Details
- Journal
- Gynecologic Oncology Reports
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1016/j.gore.2024.101670
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Yonsei University
- Inje University
- National Research Foundation of Korea
- Yonsei University College of Medicine