Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose

Male offspring of rats whose mothers consumed sucrose (5% solution) during gestation and lactation were also given the sucrose solution instead of drinking water for 3 months, and subsequently, for 1 month, they were given an aqueous extract obtained from dehydrated fruiting bodies of Pleurotus ostreatus. The offspring that consumed sucrose (experimental group) did not show differences in body weight compared with those that did not consume sucrose (control group), however, total adiposity was higher in the experimental group. In rats that consumed the aqueous extract, a decrease in the amount of cholesterol and triglycerides in blood plasma was observed, total adiposity also decreased and the average size of adipocytes in the visceral area was reduced. Consumption of the aqueous extract of P. ostreatus showed an antihyperlipidemic effect when triglyceride, cholesterol and adipose tissue levels were increased by the consumption of sucrose in rats descended from mothers who also consumed sucrose.