Choline metabolism modulates cyclic-di-GMP signaling and virulence of Pseudomonas aeruginosa in a macrophage infection model
Our study showed that P. aeruginosa Cho metabolism not only interferes host nutritional immunity, but also directly affect multiple virulence phenotypes through modulation of c-di-GMP signaling.
Authors
- Yachun Zhou (ORCID: https://orcid.org/0009-0002-0228-330X)
- Tian Zhou (ORCID: https://orcid.org/0000-0001-8557-3091)
- Weidong Zheng (ORCID: https://orcid.org/0000-0003-4295-1544)
- Anmin Ren (ORCID: https://orcid.org/0000-0001-7551-1698)
- Yinyue Deng (ORCID: https://orcid.org/0000-0003-1511-0870)
- Yingfeng Huang
- Xiangke Duan (ORCID: https://orcid.org/0000-0002-4579-8269)
- Lin Zhong (ORCID: https://orcid.org/0000-0002-1822-6919)
- Lei Liu (ORCID: https://orcid.org/0000-0001-9612-6844)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-0228-7979)
- Liang Yang (ORCID: https://orcid.org/0000-0003-0632-7568)
- Dongjing Liu (ORCID: https://orcid.org/0009-0002-5794-7994)
Institutions
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12879-024-10375-3
- Citations
- 5
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Shenzhen University
- Basic and Applied Basic Research Foundation of Guangdong Province