In vivo imaging of adipose-derived stem cell sheets on biodegradable nonwoven fabric using X-ray CT

We demonstrated not only that the thick ADSC sheets can be transplanted successfully into animals, but also that the transplanted sheets can be observed in vivo by X-ray CT, which also allows changes in the ADSC sheets to be tracked. The results suggest that the biodegradable nonwoven fabric will be a useful transplantation device to ensure cell engraftment throughout the affected area, and facilitate monitoring of the transplant's subsequent status. We expect that this transplantation device will promote the development of regenerative therapy.