COMPARISON OF THE INFORMATIONAL CONTENT OF THE HOMA AND MATSUDA INDICES AS LEADING DIAGNOSTIC INDICATORS OF INSULIN RESISTANCE

Introduction. Today, the world faces a number of challenges. Prevention of the development of severe metabolic diseases and preservation of reproductive health are among the priorities in the field of healthcare. Insulin resistance (IR) is a condition characterised by an insufficient response of muscles, liver, and adipose tissue to insulin. IR is one of the links in the development of complex disorders in women of reproductive age. Aim. This problem is relevant, so the aim of the study was to investigate the diagnostic value of the HOMA index and the Matsuda index as the leading diagnostic indicators of insulin resistance in women of early reproductive age. Materials and methods. The study involved 82 women in the age range of 18 to 20 years, 52 women formed the main study group, and the remaining 30 women – the control group. A number of studies were conducted, namely: questionnaires, measurement of anthropometric parameters (height, weight, waist circumference (WC), body mass index (BMI), laboratory parameters sex-binding globulin (SBG), follicle stimulating hormone (FSH) luteinising hormone (LH), thyroid-stimulating hormone (TSH), prolactin, dehydroepiandrosterone sulfate (DHEA-s), total testosterone, free testosterone index, HOMA-IR index, glucose tolerance test (GTT) + insulin determination, Matsuda index. Results. The correlation and increase in HOMA index was observed with the following parameters: WC r = 0.353576, BMI r = 0.36090423, duration of menstrual cycle establishment r = -0.275476711, duration of bleeding during menstruation r = -0.263068287, TSH level r = 0.212637559, DHEA-c level, r = -0.239567359, total testosterone level r = 0.241491459. The presence of correlations and an increase in the Matsuda index is with the following indicators: duration of bleeding during the menstrual cycle r = 0.263762, FSH level r = -0.222514608, total testosterone level r = -0.351298232. Conclusions. Having conducted a correlation analysis of the relationships, it can be assumed that the HOMA index can be considered the most informative laboratory method for the diagnosis of latent IR. In case of clinically expressed IR, it is permissible to use the Matsuda index.