Iron deficiency promotes intra-leaflet hemorrhage-induced aortic valve calcification: an experimental study
ID triggers TFR1-mediated intracellular iron overload, leading to fibrosis and calcification in human VICs, thereby contributing to IH-mediated valve remodeling and calcification. These findings supported the potential role of monitoring and correcting ID to slow or prevent the progression of valvular calcification.
Authors
- Huiruo Liu (ORCID: https://orcid.org/0000-0001-5171-3316)
- Yuguo Chen (ORCID: https://orcid.org/0000-0001-9501-2546)
- Chuanbao Li (ORCID: https://orcid.org/0000-0002-1224-0509)
- Zeyu Yang (ORCID: https://orcid.org/0000-0002-7223-5234)
- Zerui Wang (ORCID: https://orcid.org/0000-0003-4281-5120)
- Feng Xu (ORCID: https://orcid.org/0000-0002-4670-3727)
- Hourong Sun
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1097/js9.0000000000002208
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00