Effect of melatonin on postoperative cognitive function in elderly patients submitted to transurethral resection of the prostate under spinal anesthesia
Melatonin had no statistical effect on POCD, but a selective beneficial effect was observed in two cognitive areas. The high prevalence of preoperative cognitive impairment may be related to the lower urinary tract symptoms which were reasons for the surgery; the unexpected improvement of cognitive performance in all patients at 180 days PO may reflect alleviation of these symptoms.
Authors
- Luiz Guilherme Villares da Costa (ORCID: https://orcid.org/0000-0001-5044-9998)
- Cristiane Tavares (ORCID: https://orcid.org/0000-0002-7669-0795)
- Cláudia Maia Memória (ORCID: https://orcid.org/0000-0003-3951-3543)
- Vinícius Caldeira Quintão (ORCID: https://orcid.org/0000-0001-6459-7983)
- Alberto Nogueira da Gama Antunes (ORCID: https://orcid.org/0000-0003-4554-7440)
- Deborah Teodoro
- Maria José Carvalho Carmona
Institutions
- Hospital Israelita Albert Einstein (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Clinics
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.clinsp.2024.100562
- Citations
- 2
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Universidade de São Paulo