Synthesis of Tetracyclic-Fused Dihydroindeno[2,1-<i>b</i>]chromenes via Palladium-Catalyzed Alkyne Insertion and C–H Bond Activation
An unprecedented Pd-catalyzed cascade alkyne insertion/Heck/C-H activation reaction of <i>o</i>-iodophenyl alkenyl ethers and diarylacetylenes has been developed. Diversified tetracyclic-fused dihydroindeno[2,1-<i>b</i>]chromenes bearing a quaternary center were constructed in an efficient, straightforward, and atom-economic way with good to excellent yields. The protocol features high bonding efficiency, operational simplicity, broad substrate scope, and easy scale-up.
Authors
- Xumeng Wang
- Weiming Hu (ORCID: https://orcid.org/0000-0002-0157-1089)
- Fan Teng (ORCID: https://orcid.org/0000-0002-7971-4211)
- Huayou Hu (ORCID: https://orcid.org/0000-0003-4795-0866)
- Wenting Wu (ORCID: https://orcid.org/0000-0002-8380-7904)
- Hualan Zhou (ORCID: https://orcid.org/0000-0002-4922-2101)
- Wenting Guo (ORCID: https://orcid.org/0000-0003-0847-4318)
- Xinhui Zhao (ORCID: https://orcid.org/0000-0001-9290-301X)
- Chuanzhou Tao (ORCID: https://orcid.org/0000-0003-3254-6772)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Dimensional Imaging (United Kingdom) (GB)
- Advanced Materials and Technologies (Slovenia) (SI)
- Huaiyin Normal University (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1021/acs.joc.4c02658
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Natural Science Research of Jiangsu Higher Education Institutions of China
- National Key Research and Development Program of China