Cortical and subcortical gray matter volume and cognitive impairment in Parkinson’s disease
Compared to HCs, PD patients with CI presented significant volume reductions in the RC, LH, LT, RMFG, RPGMS, RSFGMS, and the right and left crus I regions. Consequently, as average GMV atrophy increased in the specified regions, PD patients exhibited more severe cognitive impairment than the HC group. This may be attributed to the initial pathological loss of frontal GMV (especially in the RMFG and RPGMS regions), which could subsequently lead to subcortical dysfunction.
Authors
- Sajjad Farashi (ORCID: https://orcid.org/0000-0002-5082-6391)
- Ghodratollah Roshanaei (ORCID: https://orcid.org/0000-0002-3547-9125)
- Siamak Shahidi (ORCID: https://orcid.org/0000-0001-8196-5223)
- Nariman Moradi (ORCID: https://orcid.org/0000-0001-7760-4804)
- Mohammad Ahmadpanah (ORCID: https://orcid.org/0000-0003-2908-2460)
Institutions
- Hamedan University of Medical Sciences (IR)
Publication Details
- Journal
- Applied Neuropsychology Adult
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1080/23279095.2024.2443591
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37