Correlation analysis of the impact of <i>Clonorchis sinensis</i> juvenile on gut microbiota and transcriptome in mice
This study highlighted the impact of <i>C. sinensis</i> juvenile infection on the gut microbiota and transcriptome of BALB/c mice. It induced liver inflammation, promoted intestinal villi growth, and altered goblet cell numbers. The infection also disrupted the diversity and structure of gut microbiota, particularly affecting beneficial bacteria. Transcriptome analysis revealed increased expression of genes related to immune response and detoxification processes. Important pathways affected included circadian rhythm, glutathione metabolism, and glycolysis/gluconeogenesis. Notable genes implicated included Igkv12-41, Mcpt2, Arntl, Npas2, Cry1, and Gsta1. <i>Bacteroides_sartorii</i> emerged as a potential key regulator in this interaction.
Authors
- Jiali Yao (ORCID: https://orcid.org/0000-0003-0133-6449)
- Zhanshuai Wu (ORCID: https://orcid.org/0000-0002-0509-0768)
- Boying Liang
- Yuhong Wu (ORCID: https://orcid.org/0009-0001-5822-9882)
- Zeli Tang (ORCID: https://orcid.org/0000-0002-2436-0655)
- Wei Hou (ORCID: https://orcid.org/0000-0001-9072-9812)
- Shitao Li (ORCID: https://orcid.org/0000-0002-1398-8519)
- Qiping Hu (ORCID: https://orcid.org/0000-0003-4654-5076)
- Jingwu Zheng (ORCID: https://orcid.org/0000-0002-5162-6965)
- Xiaole Liang
- Xueling Deng
Institutions
- Guangxi Medical University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1128/spectrum.01550-24
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University