Role of PCBP2 in regulating nanovesicles loaded with curcumin to mitigate neuroferroptosis in neural damage caused by heat stroke
This study successfully developed engineered cell membrane NVs-CUR with neuron-targeting properties. NVs-CUR increased the expression of PCBP2, maintained the stability of SLC7A11 mRNA, reduced ferroptosis, and ultimately alleviated hypothalamic neuroinflammation induced by heatstroke.
Authors
- Guangjun Wang (ORCID: https://orcid.org/0000-0001-5344-4594)
- Jiangwei Liu (ORCID: https://orcid.org/0000-0002-7652-9379)
- Fei Guo
- Yizhan Wu
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Xinjiang Institute of Engineering (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12951-024-02889-4
- Citations
- 7
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.29