Himalaflavones F and G, two new flavonoids from the roots of <i>Oxybaphus himalaicus</i> Edgew with anti-inflammatory activity

Himalaflavones F (<b>1</b>) and G (<b>2</b>), two new flavonoids, along with eight known ones (<b>3-10</b>)were isolated from the roots of <i>Oxybaphus himalaicus</i> Edgew. The chemical structures of these compounds were elucidated by 1D/2D NMR, UV and HR-ESI-ME data. Meanwhile, the anti-inflammatory activities of all isolates were test by using Griess method. Among them 10 μM of compounds <b>1</b>, <b>2</b>, <b>8</b> and <b>10</b> could decrease the NO release against LPS-induced RAW264.7 macrophages. The results suggested that these compounds have the potential to be developed as anti-inflammatory drugs.

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Journal
Natural Product Research
Published
2024-12-27
DOI
https://doi.org/10.1080/14786419.2024.2446705
Primary Topic
Bioactive natural compounds
Type
article
Field-Weighted Citation Impact
0.00

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article

Himalaflavones F and G, two new flavonoids from the roots of Oxybaphus himalaicus Edgew with anti-inflammatory activity

Zhuoqing Cheng, Zhaoyue Dong, Zhihua Liao, Yi Lan et al.
Natural Product Research
Bioactive natural compounds
article

Himalaflavones F and G, two new flavonoids from the roots of Oxybaphus himalaicus Edgew with anti-inflammatory activity

Zhuoqing Cheng, Zhaoyue Dong, Zhihua Liao, Yi Lan, Yiran Xiong, Guowei Wang, Xiaozhong Lan, Han Yuan, Min Chen, Nan Wang
article en

Abstract

Himalaflavones F (<b>1</b>) and G (<b>2</b>), two new flavonoids, along with eight known ones (<b>3-10</b>)were isolated from the roots of <i>Oxybaphus himalaicus</i> Edgew. The chemical structures of these compounds were elucidated by 1D/2D NMR, UV and HR-ESI-ME data. Meanwhile, the anti-inflammatory activities of all isolates were test by using Griess method. Among them 10 μM of compounds <b>1</b>, <b>2</b>, <b>8</b> and <b>10</b> could decrease the NO release against LPS-induced RAW264.7 macrophages. The results suggested that these compounds have the potential to be developed as anti-inflammatory drugs.

Natural Product Research
Tibet University (CN), Southwest University (CN)
National Natural Science Foundation of China
Zero hunger
Openalex Percentile: Top 79%
Bioactive natural compounds
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