Himalaflavones F and G, two new flavonoids from the roots of <i>Oxybaphus himalaicus</i> Edgew with anti-inflammatory activity
Himalaflavones F (<b>1</b>) and G (<b>2</b>), two new flavonoids, along with eight known ones (<b>3-10</b>)were isolated from the roots of <i>Oxybaphus himalaicus</i> Edgew. The chemical structures of these compounds were elucidated by 1D/2D NMR, UV and HR-ESI-ME data. Meanwhile, the anti-inflammatory activities of all isolates were test by using Griess method. Among them 10 μM of compounds <b>1</b>, <b>2</b>, <b>8</b> and <b>10</b> could decrease the NO release against LPS-induced RAW264.7 macrophages. The results suggested that these compounds have the potential to be developed as anti-inflammatory drugs.
Authors
- Zhuoqing Cheng
- Zhaoyue Dong (ORCID: https://orcid.org/0000-0002-7462-7688)
- Zhihua Liao
- Yi Lan
- Yiran Xiong
- Guowei Wang (ORCID: https://orcid.org/0000-0003-0762-9023)
- Xiaozhong Lan (ORCID: https://orcid.org/0000-0002-1951-5560)
- Han Yuan
- Min Chen
- Nan Wang (ORCID: https://orcid.org/0009-0003-9735-4314)
Institutions
- Tibet University (CN)
- Southwest University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1080/14786419.2024.2446705
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China