Rhodium(III)‐Catalyzed [4+2] Annulation of <i>N</i>‐Hydroxyoximes with Maleate Esters/2‐Chloroacrylates: Synthesis of Isoquinoline‐3,4‐Dicarboxylates and Isoquinoline‐3‐Carboxylates
Abstract A novel Rh(III)‐catalyzed [4+2] annulation of N ‐hydroxyoximes with maleate esters/2‐chloroacrylates is disclosed, in which diverse isoquinoline skeleton compounds were generated in moderate to excellent yields. The protocol exhibits a good compatibility of functional groups and wide scope of substrates without using any external metal oxidants. Gram‐scale and derivatization reactions were performed to show the potential utility of this transformation.
Authors
- Ye Lu (ORCID: https://orcid.org/0000-0002-7968-7508)
- Xinxin Jin (ORCID: https://orcid.org/0000-0002-6701-9430)
- Ming Bao (ORCID: https://orcid.org/0000-0002-5179-3499)
- Ning Xu (ORCID: https://orcid.org/0000-0002-4613-2151)
- Jiaqi Yu (ORCID: https://orcid.org/0000-0002-5749-2267)
- Tao Chen (ORCID: https://orcid.org/0000-0003-4392-3748)
- He Li (ORCID: https://orcid.org/0000-0003-3588-0215)
- Yuxin Li (ORCID: https://orcid.org/0000-0002-2374-8041)
- Zhiwei Wang (ORCID: https://orcid.org/0009-0008-5824-0919)
- Bin Wu (ORCID: https://orcid.org/0000-0002-3320-0442)
- Jing-Lin Liu
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
- Innovation Team (China) (HK)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1002/ejoc.202401264
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia