Mixed-methods, descriptive and observational cohort study examining feeding and growth patterns among low birthweight infants in India, Malawi and Tanzania: the LIFE study protocol
INTRODUCTION: Ending preventable deaths of newborns and children under 5 will not be possible without evidence-based strategies addressing the health and care of low birthweight (LBW, <2.5 kg) infants. The majority of LBW infants are born in low- and middle-income countries (LMICs) and account for more than 60%-80% of newborn deaths. Feeding promotion tailored to meet the nutritional needs of LBW infants in LMICs may serve a crucial role in curbing newborn mortality rates and promoting growth. The Low Birthweight Infant Feeding Exploration (LIFE) study aims to establish foundational knowledge regarding optimal feeding options for LBW infants in low-resource settings throughout infancy. METHODS AND ANALYSIS: LIFE is a formative, multisite, observational cohort study involving 12 study facilities in India, Malawi and Tanzania, and using a convergent parallel, mixed-methods design. We assess feeding patterns, growth indicators, morbidity, mortality, child development and health system inputs that facilitate or hinder care and survival of LBW infants. ETHICS AND DISSEMINATION: This study was approved by 11 ethics committees in India, Malawi, Tanzania and the USA. The results will be disseminated through peer-reviewed publications and presentations targeting the global and local research, clinical, programme implementation and policy communities. TRIAL REGISTRATION NUMBERS: NCT04002908 and CTRI/2019/02/017475.
Authors
- Christopher Duggan (ORCID: https://orcid.org/0000-0001-8083-8193)
- Lauren Spigel (ORCID: https://orcid.org/0000-0001-7846-4890)
- Eliza Fishman
- Sarah Somji (ORCID: https://orcid.org/0000-0001-6031-830X)
- Kimberly Mansen (ORCID: https://orcid.org/0000-0002-2015-2066)
- Sangappa Dhaded (ORCID: https://orcid.org/0000-0001-9575-5251)
- Megan Marx Delaney (ORCID: https://orcid.org/0000-0002-6371-8226)
- Laura Subramanian (ORCID: https://orcid.org/0000-0002-5090-664X)
- Latha G Shamanur
- Melda Phiri
- Sunil S. Vernekar (ORCID: https://orcid.org/0000-0002-0635-8041)
- Sujata Misra (ORCID: https://orcid.org/0000-0002-6427-9544)
- Friday Saidi (ORCID: https://orcid.org/0000-0003-1190-1499)
- Krysten North (ORCID: https://orcid.org/0000-0001-9283-4413)
- Linda S. Adair (ORCID: https://orcid.org/0000-0002-3670-8073)
- Emily Benotti (ORCID: https://orcid.org/0000-0003-4366-8425)
- Danielle E Tuller (ORCID: https://orcid.org/0000-0002-7643-5268)
- Roopa Bellad (ORCID: https://orcid.org/0000-0003-4383-1704)
- Karim Manji (ORCID: https://orcid.org/0000-0002-7069-6408)
- Tisungane Mvalo (ORCID: https://orcid.org/0000-0002-6775-7919)
- Linda Vesel (ORCID: https://orcid.org/0000-0003-3753-4172)
- Sanghamitra Panda
- Anne CC Lee (ORCID: https://orcid.org/0000-0003-2654-9862)
- Katelyn Fleming
- Bethany A. Caruso (ORCID: https://orcid.org/0000-0001-9738-9857)
- Shivaprasad S. Goudar (ORCID: https://orcid.org/0000-0002-8680-7053)
- Christopher R. Sudfeld (ORCID: https://orcid.org/0000-0002-3203-3638)
- Katherine Semrau (ORCID: https://orcid.org/0000-0002-8360-1391)
- Jnanindra Nath Behera
- Rodrick Kisenge (ORCID: https://orcid.org/0000-0002-3273-8136)
- Gowdar Guruprasad
- Melissa Fox Young (ORCID: https://orcid.org/0000-0002-2768-1673)
- Kate Miller (ORCID: https://orcid.org/0000-0002-6582-8031)
- Kiersten Israel‐Ballard (ORCID: https://orcid.org/0000-0002-3489-8213)
- Natalie Henrich (ORCID: https://orcid.org/0000-0002-0293-1859)
- Stephanie Martin (ORCID: https://orcid.org/0000-0002-0378-802X)
- Irving Hoffman
- Nahya Salim
- Leena Das
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2024-12-20
- DOI
- https://doi.org/10.17615/sc94-8h21
- Primary Topic
- Child Nutrition and Water Access
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation