Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment
This study underlined that combining PD-1 + Treg/PD-1 + CD8 ratio and TLS were significantly associated with prognosis and preoperative treatment response in advanced gastric cancer. Inspiringly, these indicators have the potential to elucidate the immune balance of advanced gastric cancer patients and can accurately guide subsequent therapeutic strategies.
Authors
- Hui Cao (ORCID: https://orcid.org/0000-0003-0083-936X)
- Chunchao Zhu (ORCID: https://orcid.org/0000-0002-9424-9987)
- Chen Huang (ORCID: https://orcid.org/0000-0003-2777-7365)
- Haigang Geng (ORCID: https://orcid.org/0009-0009-5765-5992)
- Xu Liu (ORCID: https://orcid.org/0000-0003-1585-436X)
- Chaojie Wang (ORCID: https://orcid.org/0000-0002-5669-916X)
- Xiang Xia (ORCID: https://orcid.org/0000-0002-8476-7916)
- Yanying Shen (ORCID: https://orcid.org/0000-0001-9195-2207)
- Yiqing Zhong (ORCID: https://orcid.org/0000-0002-0992-0810)
- Cheng‐Bei Zhou
- Danhua Xu
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12967-024-05867-4
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Natural Science Foundation of China
- Shanghai Education Development Foundation
- Shanghai Municipal Education Commission