Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates
Dosimetry analysis indicated absorbed and effective doses of [<sup>18</sup>F]CHDI-650 are well below the recommended limits, suggesting that the radioligand is suitable for clinical assessment. Based on the highest effective dose estimates, an injection of 370 MBq in humans would result in a radiation dose of 8.03 mSv.
Authors
- Longbin Liu (ORCID: https://orcid.org/0000-0003-3995-0196)
- Robert K. Doot (ORCID: https://orcid.org/0000-0003-1747-239X)
- Alan Miranda (ORCID: https://orcid.org/0000-0002-5381-015X)
- Vinod Khetarpal (ORCID: https://orcid.org/0000-0002-2175-5117)
- Jordy Akkermans (ORCID: https://orcid.org/0000-0002-1533-9504)
- Jeroen Verhaeghe (ORCID: https://orcid.org/0000-0002-4493-1902)
- Jonathan Bard (ORCID: https://orcid.org/0000-0002-5097-1361)
- Daniele Bertoglio (ORCID: https://orcid.org/0000-0003-4205-5432)
- Franziska Zajicek (ORCID: https://orcid.org/0000-0001-5410-687X)
- Steven Staelens (ORCID: https://orcid.org/0000-0003-3376-0519)
- Filipe Elvas (ORCID: https://orcid.org/0000-0001-9790-3369)
Institutions
- University of Antwerp (BE)
- CHDI Foundation (US)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s13550-024-01188-1
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- CHDI Foundation
- Fonds Wetenschappelijk Onderzoek
- Universiteit Antwerpen
- Vlaamse regering