Investigating ocular biomarkers and differential diagnosis of Alzheimer’s disease and vascular cognitive impairment based on multimodal imaging
We demonstrate that pupillary light reaction-related neurodegeneration is the common pathological change in both AD and VCI. In addition, AD is characterized by alterations in retinal spectral signatures, whereas VCI is characterized by alterations in retinal hemodynamics. These findings suggest that multimodal ophthalmic imaging may have the potential to be used as a screening tool for detecting AD and VCI.
Authors
- Kun Shang (ORCID: https://orcid.org/0000-0003-0137-0081)
- Qiushi Ren (ORCID: https://orcid.org/0000-0003-3301-9085)
- Ximeng Feng
- Zi‐Bing Jin (ORCID: https://orcid.org/0000-0003-0515-698X)
- Xuhui Chen (ORCID: https://orcid.org/0000-0001-6405-6810)
- Chuanqing Zhou (ORCID: https://orcid.org/0000-0002-9030-4993)
- Jinying Li (ORCID: https://orcid.org/0000-0002-3233-9514)
- Chunxia Jiang (ORCID: https://orcid.org/0000-0002-0013-2922)
Institutions
- Peking University (CN)
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Shenzhen Bay Laboratory (CN)
- Peking University Shenzhen Hospital (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Journal of Biomedical Optics
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1117/1.jbo.29.12.126003
- Citations
- 1
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province