Study of hepatoprotective properties of protein fractions obtained from leaves of Tagetes erecta L. and Salvia aethiopis L. plants by gel filtration chromatography on tetrachloromethane (CCl4) damaged hepatocytes of mice
The study presents data on the action of protein fractions obtained from Tagetes erectaL. and Salvia aethiopisL. plants by gel filtration chromatography on the hepatocytes of mice damaged by a 10% tetrachloromethane solution. Protein fractions of the third and fourth peaks have weak hepatoprotective properties. Each peak was also separated into several fractions by the method of ion exchange chromatography. The SDS-PAGE revealed fractions, including those with a molecular weight of 23-47 kDa, which probably participate in the protection of hepatocytes.
Authors
- Mariam Kobiashvili
- Teimuraz Tavkhelidze (ORCID: https://orcid.org/0009-0005-9618-3861)
- Marina Pirtskhalava (ORCID: https://orcid.org/0000-0002-0464-1345)
- Malkhaz Vakhania (ORCID: https://orcid.org/0009-0001-2939-0132)
- Tornike Mindiashvili
- Marina Gogodze
Institutions
- University Geomedi (GE)
Publication Details
- Journal
- MODERN ISSUES OF MEDICINE AND MANAGEMENT
- Published
- 2024-12-27
- DOI
- https://doi.org/10.56580/geomedi47
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00