Integrating Knowledge Graphs with Symbolic AI: The Path to Interpretable Hybrid AI Systems in Medicine

Knowledge Graphs (KGs) are graph-based structures that integrate heterogeneous data, capture domain knowledge, and enable explainable AI through symbolic reasoning. This position paper examines the challenges and research opportunities in integrating KGs with neuro-symbolic AI, highlighting their potential to enhance explainability, scalability, and context-aware reasoning in hybrid AI systems. Using a lung cancer use case, we illustrate how hybrid approaches address tasks such as link prediction—uncovering hidden relationships in medical data—and counterfactual reasoning—analyzing alternative scenarios to understand causal factors. The discussion is framed around TrustKG, which demonstrates how constraint validation, causal reasoning, and user-centric communication can support transparent and reliable decision-making. Additionally, we identify current limitations of KGs, including gaps in knowledge coverage, evolving data integration challenges, and the need for improved usability and impact assessment. These insights are not limited to healthcare but extend to other domains like energy, manufacturing, and mobility, showcasing the broad applicability of KGs. Finally, we propose research directions to unlock their full potential in building robust, transparent, and widely adopted real-world applications. • Explores how Knowledge Graphs enhance explainability and scalability in hybrid AI systems. • Introduces TrustKG for constraint validation and causal reasoning in healthcare. • Identifies gaps in KGs and proposes solutions for usability and evolving knowledge. • Links KG research in healthcare to applications in energy and manufacturing. • Proposes methods to improve KG data quality, scalability, and accessibility.