Genetic and Microbial Analysis of Invasiveness for Escherichia coli Strains Associated With Inflammatory Bowel Disease
This study highlights the importance of incorporating antibiotic resistance screening for invasion assays used in AIEC identification. Accurately screened invasion phenotypes identified accessory genome elements among E coli IBD isolates that correlate with their ability to invade epithelial cells. These results help explain why single genetic markers for the AIEC phylotype are challenging to identify.
Authors
- Tamia Harris-Tryon (ORCID: https://orcid.org/0000-0002-4170-7083)
- Sydney Field (ORCID: https://orcid.org/0000-0002-7824-078X)
- J.H. Kim
- Qian Cong (ORCID: https://orcid.org/0000-0002-8909-0414)
- Shahanshah Khan (ORCID: https://orcid.org/0000-0003-3052-932X)
- Lisa N. Kinch (ORCID: https://orcid.org/0000-0003-3041-2615)
- Kim Orth (ORCID: https://orcid.org/0000-0002-0678-7620)
- Josephine Ni (ORCID: https://orcid.org/0000-0003-0933-6873)
- Kevin J. Forsberg (ORCID: https://orcid.org/0000-0002-1545-8925)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-4190-3065)
- Jinhui Shen (ORCID: https://orcid.org/0000-0002-7517-086X)
- Jan‐Michael A. Klapproth
Institutions
- Southwestern Medical Center (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101451
- Citations
- 3
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- Howard Hughes Medical Institute
- Burroughs Wellcome Fund
- Welch Foundation
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- University of Texas Southwestern Medical Center
- Once Upon A Time Foundation
- Searle Scholars Program
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases