Immune deficiency phenotypes of Il2rg, Rag2 or Il2rg/Rag2 double knockout rats; establishment of human leukemia xenograft models
These findings indicate that Il2rg KO, Rag2 KO, and Il2rg/Rag2 KO rats exhibited SCID phenotypes, suggesting their potential application as immunodeficient animal models for tumor xenograft studies.
Authors
- Byeong-Cheol Kang (ORCID: https://orcid.org/0000-0002-9485-516X)
- Tomoji Mashimo (ORCID: https://orcid.org/0000-0001-7543-7301)
- Hyun-Jin Lim
- Euna Kwon
- Joo-Il Kim
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- National University College (PR)
- The University of Tokyo (JP)
Publication Details
- Journal
- Laboratory Animal Research
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s42826-024-00231-5
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea