Bioinformatics based exploration of the anti-NAFLD mechanism of Wang’s empirical formula via TLR4/NF-κB/COX2 pathway
WSF treatment effectively protects against lipid metabolism disorders and liver inflammation injury in HSHF diet-induced NAFLD mice, and its molecular mechanism might be via suppressing the TLR4/NF-κB/COX-2 inflammatory pathway to reduce the release of inflammatory cytokines in the liver.
Authors
- Suhong Chen (ORCID: https://orcid.org/0000-0001-8807-5071)
- Xinglishang He (ORCID: https://orcid.org/0000-0002-5435-0423)
- Jia-Hui Huang (ORCID: https://orcid.org/0000-0002-9568-2563)
- Shuhua Shen
- Yuzhen Huang (ORCID: https://orcid.org/0000-0002-9536-7918)
- Wanfeng Xu
- Yimeng Qiao (ORCID: https://orcid.org/0009-0008-6340-2919)
- Kungen Wang
- Guiyuan Lv (ORCID: https://orcid.org/0000-0003-2732-4905)
- Bo Li (ORCID: https://orcid.org/0000-0003-2783-9300)
- Ning Wang (ORCID: https://orcid.org/0000-0002-1849-1747)
- Yihui Zhi
- Chuanjie Zhou
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Medicine (China) (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s10020-024-01022-3
- Citations
- 8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- National Natural Science Foundation of China
- State Administration of Traditional Chinese Medicine of the People's Republic of China