Canid alphaherpesvirus 1 infection alters the gene expression and secretome profile of canine adipose-derived mesenchymal stem cells in vitro
To the best of our knowledge, this is the first study of the effects of virus infection on gene expression and secretome composition in cAD-MSCs. The outcomes of our study underscore the imperative of routine viral screening prior to the therapeutic use of cAD-MSCs. Moreover, these findings provide novel insights into the pathogenic mechanisms of CHV and pave the way for future canine stem cell and virus research.
Authors
- Tomaž Mark Zorec (ORCID: https://orcid.org/0000-0001-8191-0994)
- Šimun Naletilić (ORCID: https://orcid.org/0009-0002-5805-9892)
- Nenad Turk
- Rok Kogoj (ORCID: https://orcid.org/0000-0002-8999-4923)
- Doroteja Vlaj
- Mario Poljak (ORCID: https://orcid.org/0000-0002-3216-7564)
- Valentina Kunić (ORCID: https://orcid.org/0000-0002-0154-7652)
- Marina Prišlin (ORCID: https://orcid.org/0000-0002-1169-2060)
- Dragan Brnić (ORCID: https://orcid.org/0000-0002-7318-8337)
- Vjekoslava Kostanić (ORCID: https://orcid.org/0009-0009-6720-1329)
Institutions
- University of Ljubljana (SI)
- University of Zagreb (HR)
- Croatian Veterinary Institute (HR)
Publication Details
- Journal
- Virology Journal
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12985-024-02603-8
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Javna Agencija za Raziskovalno Dejavnost RS
- Hrvatska Zaklada za Znanost
- European Regional Development Fund