Correlation of iPTH, Serum Calcium, and Serum Phosphorous with Different Stages of Chronic Kidney Disease

Abstract: Background: CKD-mineral and bone disorders (CKD-MBD) include abnormalities in blood calcium (Ca), phosphate (P), and parathyroid hormone (PTH), as well as bony derangements and vascular calcification, which are increasingly more frequent in patients with chronic kidney disease (CKD) stages 4 and 5. Objective: To assess the correlation of chronic kidney disease, mineral, and bone disorder (CK-MBD) with stages of CKD. Materials and Methods: This is a cross-sectional, study conducted at the Tabba Kidney Institute, Serum levels of calcium, phosphate, and intact PTH (iPTH) were measured as part of the study at baseline. The statistical package of Social Sciences version 22 was used to enter, sort, and analyze data. To assess the risk of vascular calcification in different stages of CKD, odds ratio (OR) test was performed, keeping confidence interval as 95% and OR of 1 as positive risk of outcome after exposure. Result: A total of 82 patients were enrolled in the study with a mean age of 59.6 ± 13.3 years. The results indicated positive odds of vascular calcification in CKD stage V with 1.418 and Confidence interval of 95% as a lower bound and upper bound of 1.121-10.817, indicating higher chances of vascular calcification in stage V patients. Similarly, CKD stage IV reported 0.042 OR with lower and upper bound of 0.352-4.162 confidence interval respectively. Conclusion: This study concludes that CKD progression is directly associated with Bone mineral disorders and allied complications, including the risk of vascular calcification in patients which increases from stage III to V.