T14diLys/DOPE Liposomes: An Innovative Option for siRNA-Based Gene Knockdown?
Liposomes produced with extrusion were more reproducible and provided enhanced particle properties. The physicochemical characterization and in vitro experiments showed that an N/P ratio of 5 was the most promising ratio for siRNA delivery.
Authors
- Christian Wölk (ORCID: https://orcid.org/0000-0002-8067-7307)
- Frank Erdmann (ORCID: https://orcid.org/0000-0001-5261-0984)
- Henrike Lucas (ORCID: https://orcid.org/0000-0002-2494-5303)
- Stephanie Krüger (ORCID: https://orcid.org/0000-0002-7159-8316)
- Maria Krabbes
- Sophie Meinhard
- Karsten Mäder (ORCID: https://orcid.org/0000-0003-1613-6976)
Institutions
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-12-26
- DOI
- https://doi.org/10.3390/pharmaceutics17010025
- Citations
- 1
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.23