Integrating electrospun aligned fiber scaffolds with bovine serum albumin-basic fibroblast growth factor nanoparticles to promote tendon regeneration
The aligned and random PCL fiber scaffolds containing bFGF nanoparticles were successfully prepared, and their physical and chemical properties were characterized. The aPCL + bFGF scaffold could promote the expression of the related genes and proteins of tendon-forming, facilitating tendon differentiation. In the rat Achilles tendon defect experiments, the aPCL + bFGF exhibited excellent tendon regeneration effects.
Authors
- Jian Song (ORCID: https://orcid.org/0000-0002-2924-6640)
- Long Li (ORCID: https://orcid.org/0000-0003-0363-8184)
- Jiajia Xue (ORCID: https://orcid.org/0000-0002-7209-7935)
- Yuwan Li (ORCID: https://orcid.org/0000-0001-8959-6805)
- Feng Tian (ORCID: https://orcid.org/0000-0001-8601-1023)
- Pengfei Lei (ORCID: https://orcid.org/0000-0001-9341-4568)
- Hongde Wang (ORCID: https://orcid.org/0000-0002-2512-0100)
- Zhen Ge (ORCID: https://orcid.org/0009-0001-1525-8579)
- Longfei Li (ORCID: https://orcid.org/0000-0002-9783-4567)
- Ziming Liu (ORCID: https://orcid.org/0000-0002-9354-137X)
Institutions
- Guizhou University (CN)
- Zunyi Medical University (CN)
- Peking University (CN)
- Guizhou Minzu University (CN)
- First People’s Hospital of Zunyi (CN)
- Peking University Third Hospital (CN)
- First People's Hospital of Nanning (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-12-27
- DOI
- https://doi.org/10.1186/s12951-024-03022-1
- Citations
- 14
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.69
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities