Single nucleotide polymorphism of IGF-1R (rs2229765) in acne and/or its severity

Acne vulgaris is a common inflammatory disease of pilosebaceous glands diagnosed by dermatologists in teenagers. During puberty, a peak in the levels of hormones (growth factors and its terminal mediator insulin-like growth factor-1 (IGF-1)) is observed that plays a vital role in acne pathogenesis. IGF-1 and its polymorphism are known to positively correlate with acne and/or its severity. However, the role of polymorphism of IGF-1 receptor (IGF-1R) in acne and/or its severity has not yet been elucidated. Therefore, the study aimed to assess the association of IGF-1R polymorphism with the occurrence of acne and its severity. IGF-1R polymorphism was analyzed in acne patients (n = 100) and controls (n = 100) by the restriction fragment length polymorphism. IGF-1R polymorphism was found to be evenly distributed among the controls and patients. Although IGF-1 polymorphism positively correlates with acne and/or its severity, the polymorphism of its receptor IGF-1R was not significantly associated with acne. Furthermore, no significant association was observed between IGF-1R polymorphism and IGF-1R expression at messenger ribonucleic acid (mRNA) and protein level. A similar study with a larger study populations may be planned to validate or refute the observed findings.