Pharmacokinetics of cisplatin in the systemic versus hyperthermic intrathoracic or intraperitoneal chemotherapy
The current study demonstrated that, in the perfusate, AUC<sub>0-24h</sub> and C<sub>max</sub> of cisplatin was significantly higher in the group of HITHOC compared to that of HIPEC, and that, in the plasma, AUC<sub>0-24h</sub> and C<sub>max</sub> of cisplatin was lower in the group of HITHOC compared to that of HIPEC or SC group. This study provided pharmacokinetic evidence to further support the concept that topical application of chemotherapeutic drug through minimally invasive HITHOC or HIPEC may enhance local exposure compared to systemic chemotherapy for the patients with malignant pleural effusion or ascites.
Authors
- Cheng‐Gong Liao (ORCID: https://orcid.org/0000-0002-7624-0196)
- Yan Hou (ORCID: https://orcid.org/0000-0002-1960-4221)
- Jie Song (ORCID: https://orcid.org/0000-0003-1024-9021)
- Mu Wei (ORCID: https://orcid.org/0000-0001-6365-1060)
- Lili Liu (ORCID: https://orcid.org/0000-0002-6035-3583)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-7251-1622)
- Yun Wang (ORCID: https://orcid.org/0000-0001-9438-5586)
- Dongxu Chen (ORCID: https://orcid.org/0000-0002-1414-3163)
- Yu Chen (ORCID: https://orcid.org/0000-0001-7387-1198)
- Linna Liu
- Wen Hu (ORCID: https://orcid.org/0000-0002-8961-437X)
Institutions
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cancer Chemotherapy and Pharmacology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1007/s00280-024-04727-8
- Citations
- 7
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China