Identification of TIG1 Associated Molecular Targets for Breast Cancer Using Bioinformatic Approach

e-posta/e-mail: [email protected]/[email protected] Kabul Tarihi/Accepted: Tazarotene-induced gene 1 (TIG1) is involved in modulating the α-tubulin modification and effectively inhibiting tumor growth. In this bioinformatics study, we aim to propose novel therapeutic targets in breast cancer by utilizing differentially expressed genes (DEGs) of TIG1 in inflammatory breast cancer (IBC) and examining their correlation with the molecular and immune subtypes. Using the GEO2R tool, we analyzed DEGs in the GSE30543 dataset, specifically comparing suppressed TIG1 groups with control samples from SUM149 cells. Functional annotation analysis of DEGs were explored using SRplot with data from STRING (|log2(FC)| >2 and p