PTGES3 proteolysis using the liposomal peptide-PROTAC approach
Our findings revealed that the highly selective PTGES3 proteolysis is a potential therapeutic strategy for HCC, and PTGES3 degraders PTGES3-PROTACs can be developed as safe and effective drugs for HCC treatment.
Authors
- Huansong Li
- Yangsui Liu
- Jiaqi Zhang
- Shiwei Liu (ORCID: https://orcid.org/0000-0002-0396-9883)
- Xinyu Mao (ORCID: https://orcid.org/0009-0006-3081-1252)
- Fukang Yuan (ORCID: https://orcid.org/0000-0001-8495-3818)
- Hui Dong (ORCID: https://orcid.org/0000-0002-8463-2413)
Institutions
- Jiangsu Normal University (CN)
- Shanxi Medical University (CN)
- Xuzhou Central Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Shanxi Fenyang Hospital (CN)
- Southeast University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13062-024-00580-0
- Citations
- 3
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.70