Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis
These findings revealed a metabolic reprogramming from SCD-dependent to FADS2-dependent desaturation during cancer EMT and progression, which concurrently supports EMT plasticity. Targeting desaturation reprogramming represents a potential vulnerability for cancer metabolic therapy.
Authors
- Jing Zhao (ORCID: https://orcid.org/0000-0002-1364-8194)
- Jinqin Qian (ORCID: https://orcid.org/0000-0002-5549-5800)
- Qiaobing Xu (ORCID: https://orcid.org/0000-0001-7323-7795)
- Fukai Chen (ORCID: https://orcid.org/0000-0001-9539-6463)
- Hyeon Jeong Lee (ORCID: https://orcid.org/0000-0002-2417-9338)
- Yu Xia (ORCID: https://orcid.org/0000-0001-8694-9900)
- Yanqing Gong (ORCID: https://orcid.org/0000-0003-0410-6489)
- Ji‐Xin Cheng (ORCID: https://orcid.org/0000-0002-5607-6683)
- Yihui Zhou (ORCID: https://orcid.org/0000-0002-8281-7430)
- Yamin Li (ORCID: https://orcid.org/0000-0002-5535-1807)
- Wenpeng Zhang (ORCID: https://orcid.org/0000-0002-7018-930X)
- Liqun Zhou (ORCID: https://orcid.org/0000-0003-2795-9038)
- Zhicong Chen (ORCID: https://orcid.org/0000-0002-7549-4696)
Institutions
- Boston University (US)
- Tufts University (US)
- Peking University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Peking University First Hospital (CN)
- Zhejiang University (CN)
- Guangzhou Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1002/cac2.12644
- Citations
- 8
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.28
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation