Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes
Our results suggest innovative and novel therapeutic strategies by stratifying melanoma samples through proteomic profiling, offering a spectrum of novel therapeutic interventions and prospects for combination therapy.
Authors
- Aniel Sánchez (ORCID: https://orcid.org/0000-0002-0278-8802)
- Sarolta Kárpáti
- Beáta Szeitz (ORCID: https://orcid.org/0000-0001-6414-0537)
- Jeovanis Gil (ORCID: https://orcid.org/0000-0003-3601-3893)
- Indira Plá (ORCID: https://orcid.org/0000-0002-0839-7829)
- Balázs Győrffy (ORCID: https://orcid.org/0000-0002-5772-3766)
- Letícia Szadai
- Lazaro Hiram Betancourt (ORCID: https://orcid.org/0000-0001-8207-7041)
- Zoltán G. Páhi (ORCID: https://orcid.org/0000-0002-3428-553X)
- Natália Pinto de Almeida (ORCID: https://orcid.org/0000-0002-8851-8669)
- Gilberto B. Domont (ORCID: https://orcid.org/0000-0002-1329-6483)
- Johan Malm (ORCID: https://orcid.org/0000-0002-9365-7313)
- Fábio César Sousa Nogueira (ORCID: https://orcid.org/0000-0001-5507-7142)
- Yonghyo Kim (ORCID: https://orcid.org/0000-0002-4447-9864)
- Tibor Pankotai (ORCID: https://orcid.org/0000-0001-9810-5465)
- D. Pal (ORCID: https://orcid.org/0000-0002-9426-487X)
- Elisabet Wieslander
- Áron Bartha (ORCID: https://orcid.org/0000-0003-0395-243X)
- Magdalena Kuras (ORCID: https://orcid.org/0000-0002-9479-423X)
- David Fenyö (ORCID: https://orcid.org/0000-0001-5049-3825)
- Nicole Woldmar (ORCID: https://orcid.org/0000-0002-5387-1059)
- Roger Appelqvist (ORCID: https://orcid.org/0000-0001-7450-7216)
- Anna A. Ascsillán (ORCID: https://orcid.org/0000-0002-9415-6887)
- Jimmy Rodriguez Murillo
- Attila Marcell Szász (ORCID: https://orcid.org/0000-0003-2739-4196)
- Zsuzsanna Újfaludi (ORCID: https://orcid.org/0000-0003-4738-0963)
- Viktória Doma
- Péter Horvatovich (ORCID: https://orcid.org/0000-0003-2218-1140)
- Jéssica de Siqueira Guedes (ORCID: https://orcid.org/0000-0002-8061-1623)
- Botond L. Szabolcs
- István Balázs Németh (ORCID: https://orcid.org/0000-0003-0161-4277)
- Krzysztof Pawlowski
- Ho Jeong Kwon (ORCID: https://orcid.org/0000-0002-6919-833X)
- György Marko‐Varga
- Petra Nikolett Péter
- Lajos V. Kemény (ORCID: https://orcid.org/0000-0002-8233-1844)
Institutions
- Semmelweis University (HU)
- Universidade Federal do Rio de Janeiro (BR)
- University of Groningen (NL)
- Warsaw University of Life Sciences (PL)
- Lund University (SE)
- Yonsei University (KR)
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- Institute for Systems Biology (US)
- Skåne University Hospital (SE)
- Thermo Fisher Scientific (United States) (US)
- Korea Research Institute of Chemical Technology (KR)
- New York University (US)
- Hungarian Academy of Sciences (HU)
- HUN-REN Research Centre for Natural Sciences (HU)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- International Journal of Dermatology
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1111/ijd.17586
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- European Commission
- Semmelweis Egyetem
- Hungarian Scientific Research Fund
- Magyar Tudományos Akadémia
- Fru Berta Kamprads Stiftelse
- Innovációs és Technológiai Minisztérium
- Szegedi Tudományegyetem
- National Cancer Institute
- Moonshot Research and Development Program
- Cancer Moonshot