Long-term outcomes of the patients with Cushing syndrome after endocrine remission

Purpose: The study aimed to evaluate metabolic parameters and bone density measurements during the active phase and after long-term remission, as well as to present long-term follow-up results of patients with Cushing Syndrome. Materials and Methods: In 20 patients with Cushing Syndrome, weight, waist circumference, fasting plasma glucose, lipid parameters, blood pressure and bone mineral density were evaluated during the active disease and after endocrine remission. Results: All patients were female, premenopausal with mean age of 35±9.5 (range 27-45). During the long-term follow-up (median 60 months), weight (87.6±21.2 vs 71.1±18.8) and waist circumference (98.02±11.5,) were decreased significantly compared to baseline measurements. While total cholesterol and triglyceride values were similar between before and after remission, LDL cholesterol (143.6±35.8 vs 127.7±37.06) was decreased significantly in all patients. During the hormonal remission, 63.6% of patients’ antihypertensive medication was discontinued. Bone mineral density in lumbar spine was increased compared to the baseline values of all patients. Conclusion: Metabolic parameters and bone status were improved during the long-term follow-up time in patients with Cushing syndrome. Age, gender and duration of hypercortisolism or following time can influence the recovery of these comorbidities.