Disturbed Spatial <scp>WNT</scp> Activation—A Potential Driver of the Reticularized Skin Phenotype in Systemic Sclerosis
We demonstrate an association of the "reticularized" skin phenotype in SSc with a profound loss of physiologic spatial WNT/β-catenin-activation. Rescuing the spatial WNT/β-catenin-activation might help restore the physiologic skin organization in future therapeutic approaches of fibrosing disorders.
Authors
- Christina Bergmann (ORCID: https://orcid.org/0000-0001-5257-9171)
- Michael Sticherling (ORCID: https://orcid.org/0000-0001-9396-3938)
- Sara Chenguiti Fakhouri
- Jörg H. W. Distler (ORCID: https://orcid.org/0000-0001-7408-9333)
- Clara Dees (ORCID: https://orcid.org/0000-0001-5443-0602)
- Moritz Ronicke (ORCID: https://orcid.org/0000-0001-8828-0980)
- Lukas Konstantinidis
- Ralf S. Schmid (ORCID: https://orcid.org/0000-0002-1721-5775)
- Alexandru‐Emil Matei (ORCID: https://orcid.org/0000-0003-1248-3145)
- Georg Andreas Schett (ORCID: https://orcid.org/0000-0001-8740-9615)
- Raymund E. Horch (ORCID: https://orcid.org/0000-0002-6561-2353)
- Aleix Rius Rigau (ORCID: https://orcid.org/0000-0002-0871-306X)
- Ingo Ludolph (ORCID: https://orcid.org/0000-0003-4806-7717)
- Alexander Kreuter (ORCID: https://orcid.org/0000-0003-2275-499X)
- Markus Eckstein (ORCID: https://orcid.org/0000-0001-5418-3349)
- Yinan Li (ORCID: https://orcid.org/0000-0001-8934-9361)
- Honglin Zhu (ORCID: https://orcid.org/0000-0001-8724-2835)
- Carola Berking
- Carol I. Geppert
Institutions
- Central South University (CN)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Düsseldorf University Hospital (DE)
- HELIOS St. Elisabeth Klinik Oberhausen (DE)
- Xiangya Hospital Central South University (CN)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1002/art.43094
- Citations
- 2
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung