Comprehensive Classification of Surgically Resected Pituitary Neuroendocrine Tumors: Updates From a Single-Institution Experience Based on the WHO 5th Edition
This comprehensive analysis of surgically resected PitNETs using the new WHO5 classification provides valuable insights into the distribution of the subtypes in the surgical cohort. Key findings were the predominant gonadotroph PitNET, the absence of lactotroph PitNET, and the rarity of null cell tumors in surgical cases. The lack of lactotrophs was mainly due to medical treatment. This study highlights the discrepancy between serological and immunohistochemical findings of SF1-lineage PitNETs. While metastatic PitNET cases showed poor prognosis, the predictive value of the French grading system for PitNET requires further validation through extended follow-up.
Authors
- Yong Hwy Kim (ORCID: https://orcid.org/0000-0001-9009-4191)
- Haeryoung Kim (ORCID: https://orcid.org/0000-0002-4205-9081)
- Jae‐Kyung Won (ORCID: https://orcid.org/0000-0003-1459-8093)
- Sung‐Hye Park (ORCID: https://orcid.org/0000-0002-8681-1597)
- Eric Eunshik Kim (ORCID: https://orcid.org/0000-0001-5020-9150)
- Kyeong Cheon Jung (ORCID: https://orcid.org/0000-0002-7741-7184)
- Jin Woo Park (ORCID: https://orcid.org/0000-0003-0801-8208)
- Hyunhee Kim (ORCID: https://orcid.org/0000-0003-3353-1628)
Institutions
- Seoul National University (KR)
- Yonsei University (KR)
- Severance Hospital (KR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Korean Medical Science
- Published
- 2024-12-26
- DOI
- https://doi.org/10.3346/jkms.2025.40.e56
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Health and Welfare
- Korea Health Industry Development Institute