An exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans
The present study suggests that low doses (5-10 mg) of mitragynine may cause subjective feelings of stimulation and enhance attention, while the highest dose (40 mg) may cause inhibitory feelings of amnesia and distress. Mitragynine doses up to 40 mg were well tolerated in this group.
Authors
- Ornella Corazza (ORCID: https://orcid.org/0000-0001-7371-319X)
- Kim P. C. Kuypers (ORCID: https://orcid.org/0000-0001-7634-3809)
- Johannes G. Ramaekers (ORCID: https://orcid.org/0000-0003-4553-376X)
- Eef L. Theunissen (ORCID: https://orcid.org/0000-0002-6071-1758)
- Mauro Cavarra (ORCID: https://orcid.org/0000-0002-5216-3157)
- Giuseppe Bersani (ORCID: https://orcid.org/0000-0002-4571-3261)
- Riccardo Paci
- Massimo Pasquini (ORCID: https://orcid.org/0000-0003-3959-8137)
- Elisabeth Prevete (ORCID: https://orcid.org/0000-0002-8053-7662)
- Johannes T. Reckweg (ORCID: https://orcid.org/0000-0001-7916-6334)
- Sabrina Ritscher (ORCID: https://orcid.org/0000-0002-6718-2692)
- Stefan W. Toennes (ORCID: https://orcid.org/0000-0002-1774-3201)
Institutions
- Goethe University Frankfurt (DE)
- University of Hertfordshire (GB)
- University of Trento (IT)
- Maastricht University (NL)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1007/s00213-024-06734-2
- Citations
- 7
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 3.27