Echinochrome-A Attenuates Arterial Thrombosis Complications in the Liver and Kidney in Rats

Background: Arterial thrombosis represents the most commonly feared consequence of cardiovascular disease and a leading cause of death globally. Cardiovascular disease, liver, and kidney are closely linked conditions, and disease in one organ can lead to dysfunction in the other. Objective: The current research aims to examine the therapeutic impact of Ech-A on arterial thrombosis induced by FeCl3 complications on liver and kidney function. Materials and methods: Twenty-four rats were assigned into four sham groups (n= 6), and thrombotic model groups were orally administered 2% DMSO, while the other groups were treated with two dosages of Ech-A (1 and 10 mg/kg, body weight). After seven days of administration, the left common carotid arteries of all groups were exposed to 50% ferric chloride for 10 min, except those of the sham group rats exposed to normal saline. Results: The oral administration of Ech-A caused a significant increase in partial thromboplastin time, prothrombin time, glutathione, catalase, nitric oxide, and glutathione S-transferase. While aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase activities as well as creatinine, uric acid, urea, and malondialdehyde concentrations were significantly decreased (p< 0.05). The histological examination revealed a definite improvement in the liver and kidney tissues in the Ech-A groups. Conclusion: The current investigation revealed that arterial thrombosis induced by FeCl3 in rats causes complications in the kidneys and liver. Additionally, it demonstrates the beneficial impact of Ech-A on coagulation parameters and liver and kidney function. Despite this, the current study has few limitations. Firstly, the molecular mechanism regarding the protective effect of Ech-A on liver and kidney complications caused by arterial thrombosis has not been investigated. Secondly, no reference drug has been utilised to compare with Ech-A. conclusion: The current investigation revealed that the arterial thrombosis induced by FeCl3 in rats causes complications in the liver and kidney. Additionally, showing the ameliorative effect of Ech-A on coagulation parameters and liver and kidney function.