SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β
SPP1 + Macs increase the secretion of TNF-α and IL-1β via the NF-kappa B pathway to promote HNSCC cell proliferation, and TNF-α and IL-1β in turn upregulate the expression of OPN in tumor cells and macrophages; thus, SPP1 + Macs may be a candidate target through which antitumor efficacy can be enhanced.
Authors
- Chun Liu (ORCID: https://orcid.org/0000-0001-5376-9196)
- Chuwen Li (ORCID: https://orcid.org/0000-0002-5932-8188)
- Jianjun Zhang (ORCID: https://orcid.org/0000-0002-0045-8316)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-6400-6052)
- Kun Wu (ORCID: https://orcid.org/0000-0002-4813-5671)
- Haiyan Guo (ORCID: https://orcid.org/0000-0002-1952-2648)
- Peisong Zhai
Institutions
- Central South University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Shanghai Jian Qiao University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13046-024-03255-w
- Citations
- 42
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 10.10
Funders
- National Natural Science Foundation of China