Effect of depressive symptoms on health services utilization in the HIV and hepatitis C co-infected population in Canada

Depression is common among people living with HCV and HIV, which contributes to health services utilization (HSU). It is unknown whether successful HCV treatment affects this. We examined depressive symptoms and HSU in people co-infected with HIV-HCV and their association with sustained virologic response (SVR) during the direct-acting antiviral era. We predicted depressive symptoms by a random forest classifier in the Canadian Co-infection Cohort. HSU was measured by inpatient and out-patient visits in the previous six months. We fit zero-inflated negative binomial models. Of the 1153 HCV RNA+participants, 530 were treated and of them, 95% achieved SVR. Without SVR, inpatient and out-patient visits were 17% and 5% higher among those with depressive symptoms than those without respectively; with SVR, this association disappeared. SVR was associated with 24% fewer inpatient visits. Thus, depressive symptoms were associated with a modest increase in HSU, and SVR appears to attenuate this effect.

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Publication Details

Journal
AIDS Care
Published
2024-12-25
DOI
https://doi.org/10.1080/09540121.2024.2432801
Primary Topic
HIV/AIDS Research and Interventions
Type
article
Field-Weighted Citation Impact
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article

Effect of depressive symptoms on health services utilization in the HIV and hepatitis C co-infected population in Canada

Mark Hull, Sharon Walmsley, Curtis Cooper, Marina B. Klein et al.
AIDS Care
HIV/AIDS Research and Interventions
article

Effect of depressive symptoms on health services utilization in the HIV and hepatitis C co-infected population in Canada

Mark Hull, Sharon Walmsley, Curtis Cooper, Marina B. Klein, Gayatri Marathe, Erica E. M. Moodie, Charlotte Lanièce Delaunay, Valérie Martel‐Laferrière, Marie‐Josée Brouillette, Joseph Cox, Alexander Wong
article en

Abstract

Depression is common among people living with HCV and HIV, which contributes to health services utilization (HSU). It is unknown whether successful HCV treatment affects this. We examined depressive symptoms and HSU in people co-infected with HIV-HCV and their association with sustained virologic response (SVR) during the direct-acting antiviral era. We predicted depressive symptoms by a random forest classifier in the Canadian Co-infection Cohort. HSU was measured by inpatient and out-patient visits in the previous six months. We fit zero-inflated negative binomial models. Of the 1153 HCV RNA+participants, 530 were treated and of them, 95% achieved SVR. Without SVR, inpatient and out-patient visits were 17% and 5% higher among those with depressive symptoms than those without respectively; with SVR, this association disappeared. SVR was associated with 24% fewer inpatient visits. Thus, depressive symptoms were associated with a modest increase in HSU, and SVR appears to attenuate this effect.

AIDS CareVol. 37(2)
University of Ottawa (CA), University of Toronto (CA), St. Paul's Hospital (CA), McGill University Health Centre (CA), University of Saskatchewan (CA), Centre for Advancing Health Outcomes (CA), Centre Hospitalier de l’Université de Montréal (CA), HIV Legal Network (CA), McGill University (CA)
Good health and well-being
Openalex Percentile: Top 70%
HIV/AIDS Research and Interventions
DOISourceOpenAlex
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